Hydrochlorothiazide had no adverse effects on the fertility of mice and rats of either sex in studies wherein these species were exposed, via their diet, to doses valsartan canadian farmacia of up to 100 and mg kg, respectively, prior to mating and throughout gestation. Symptoms of overdose may include unusually fast or slow heartbeat, severe dizziness or fainting. Therapy with any combination of valsartan and hydrochlorothiazide will be associated with both sets of dose-independent side effects. Carcinogenesis, Mutagenesis, Impairment of Fertility Valsartan Hydrochlorothiazide No carcinogenicity, mutagenicity or fertility studies have been conducted with the combination of valsartan and hydrochlorothiazide. In patients with an activated renin-angiotensin system, such as volume- and or salt-depleted patients receiving high doses of diuretics, symptomatic hypotension may occur. Valsartan is indicated for treatment of high blood pressure, of congestive heart failure CHF and post-myocardial infarction MI. Rasilez, known as Tekturna in the US works by directly inhibiting renin to reduce the effects caused by an over-active renin system9.